What is troxerutin used for?
Troxerutin is a flavonoid found in the skin that can be prescribed for varicose veins and disorders of blood circulation. This compound strengthens the walls of blood vessels and is an antioxidant. It is generally taken as a capsule after meals or during the meal. It should be taken for two to four weeks and should be repeated at regular intervals. It may be used alone or in combination with other medications, such as aspirin and diuretics.
While the most common use of troxerutin is for the treatment of chronic varicosity, its other uses include improving lipid abnormalities, glucose intolerance, and oxidative stress. In a study of rats, TRX showed improvement in several metabolic diseases and lipid abnormalities. Researchers found that it helped prevent and treat the sequelae of apoplexy. In addition to its effects on blood viscosity and platelet aggregation, TRX also improved cognitive function and was effective in protecting against the formation of thrombogenesis.
When troxerutin was administered to diabetic rats, the results were impressive. The drug reduced heart/body weight ratio. However, it did not lower blood pressure or plasma triglyceride levels. It also decreased plasma ROS. In addition, the drug reduced plasma triglycerides and lowered blood glucose levels. These positive effects were evident in the DM-induced model.
A study in 2013 found that troxerutin inhibited the development of oxidative stress and cognitive impairment in rats. Its effects were attributed to the fact that it activates the AKT/NF-kB signaling pathway. This could explain why it has been prescribed for many conditions. So, if you suffer from varicose veins, troxerutin may be right for you.
The chemical troxerutin is a form of rutin derived from Sophora japonica. The compound has many medicinal properties and is a natural bioflavonoid. It controls the production of reactive oxygen species, improves blood vessel flexibility, and reduces the risk of hemorrhoidal disease. It has also shown promising results in clinical trials. It has an interesting effect on blood viscosity.
Researchers have shown that troxerutin can protect the pancreatic b cells. They showed that it can reverse the STZ-induced inhibition of p-AKT protein expression. Hence, the drug may have beneficial effects in diabetes and other diseases. For example, it can improve blood glucose levels and reduce the incidence of diabetes and metabolic syndrome. This bioflavonoid is effective in preventing cardiomyopathy and edema.
In clinical trials, troxerutin improves hepatic lipid metabolism. It also increases insulin sensitivity in peripheral tissues. In addition, it decreases oxidative stress and reduces the risk of ectopic lipid deposition. Further, it influences the activities of CYP family enzymes.
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